Age and estrogen-based hormone therapy affect systemic and local IL-6 and IGF-1 pathways in women
| Autor: | Markku Alen, Sarianna Sipilä, Jaakko Kaprio, Jukka Puolakka, Maarit Ahtiainen, Paula H. A. Ronkainen, Eija Pöllänen, Vuokko Kovanen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Aging medicine.medical_specialty medicine.drug_class medicine.medical_treatment Gene Expression Adipose tissue 030209 endocrinology & metabolism Polymerase Chain Reaction Article Receptor IGF Type 1 03 medical and health sciences 0302 clinical medicine Internal medicine Leukocytes medicine Humans Muscle Skeletal Interleukin 6 030304 developmental biology 0303 health sciences biology Interleukin-6 Estrogen Replacement Therapy Muscle weakness Skeletal muscle Hormone replacement therapy (menopause) General Medicine Middle Aged medicine.anatomical_structure Endocrinology Adipose Tissue Estrogen biology.protein RNA Female Hormone therapy Geriatrics and Gerontology medicine.symptom Hormone |
| Zdroj: | AGE; Vol 34 |
| ISSN: | 1574-4647 0161-9152 |
| DOI: | 10.1007/s11357-011-9298-1 |
| Popis: | A thorough understanding of the role of estrogens on aging-related muscle weakness is lacking. To clarify the molecular mechanisms underlying the effects of hormone replacement therapy (HRT) on skeletal muscle, we analyzed systemic protein and local mRNA levels of factors related to interleukin 6 (IL-6) and insulin-like growth factor 1 (IGF-1) pathways in 30- to 35-year-old (n = 14) women (without hormonal contraceptives) and in 54- to 62-year-old monozygotic female twin pairs discordant for HRT (n = 11 pairs, mean duration of HRT 7.3 ± 3.7 years). Biopsies were taken from vastus lateralis muscle and from abdominal adipose tissue. We found, first, that the systemic levels of IL-6 receptors sIL-6R and sgp130 are sensitive to both age and HRT concomitant with the changes in body composition. The serum levels of sgp130 and sIL-6R were 16% and 52% (p ≤ 0.001 for both variables) higher in postmenopausal women than in premenopausal women, and 10% and 9% lower (p = 0.033 and p |
| Databáze: | OpenAIRE |
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