Antiproliferative Effect of Alcoholic Extracts of Some Gabonese Medicinal Plants on Human Colonic Cancer Cells
| Autor: | Eba François, Feuya tchouya Guy Raymond, Mengome Line-Edwige, Nsi-Emvo Edouard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Biology
Vitaceae Araceae law.invention Magnoliopsida law Drug Discovery Humans Cissus Gabon Medicinal plants IC50 Cell Proliferation Plants Medicinal Traditional medicine Plant Extracts biology.organism_classification Cissus debilis Dieffenbachia seguine Petersianthus macrocarpus Piptadeniastrum africanum antiproliferative activity CaCo-2 cells Antineoplastic Agents Phytogenic Complementary and alternative medicine Colonic Neoplasms Caco-2 Cells Phytotherapy Plant Structures Research Paper |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 6, No 2 (2009) |
| ISSN: | 0189-6016 |
| Popis: | Extracts from Piptadeniastrum africanum Brenan (Mimosaceae), Petersianthus macrocarpus (Breauv) L. (Lecydaceae), Cissus debilis Planch (Vitaceae) and Dieffenbachia seguine Jacq. (Araceae) were tested in vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of Piptadeniastrum africanum (G-PAR), the leaves of Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition concentrations (IC50) of 15 μg/ml, 17 μg/ml and 25 μg/ml respectively. Only one extract (leaves of Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration (IC50) higher than 50 μg/ml.Keywords: Cissus debilis; Dieffenbachia seguine; Petersianthus macrocarpus; Piptadeniastrum africanum; antiproliferative activity; CaCo-2 cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|