Marine Bacterial Compounds Evaluated by In Silico Studies as Antipsychotic Drugs Against Schizophrenia

Autor: Arthur James Rathinam, Charli Deepak Arulanandam, Hans-Uwe Dahms, Dhinesh Kumar Thiyagarajamoorthy, Muthukumar Krishnan, Santhosh Gokul Murugaiah
Rok vydání: 2018
Předmět:
Zdroj: Marine Biotechnology. 20:639-653
ISSN: 1436-2236
1436-2228
DOI: 10.1007/s10126-018-9835-3
Popis: Schizophrenia (SCZ) is one of the brain disorders which affects the thinking and behavioral skills of patients. This disorder comes along with an overproduction of kynurenic acid in the cerebrospinal fluid and the prefrontal cortex of SCZ patients. In this study, marine bacterial compounds were screened for their suitability as antagonists against human kynurenine aminotransferase (hKAT-1) which causes the synthesis of kynurenic acid downstream which ultimately causes the SCZ disorder according to the kynurenic hypothesis of SCZ. The marine actinobacterial compound bonactin shows more promising results than other tested marine compounds such as the histamine H2 blocker famotidine and indole-3-acetic acid (IAC) from docking and in silico toxicological studies carried out here. The obtained results of the Grid-based Ligand Docking with Energetics (Glide) scores of extra-precision (XP) Glide against the target protein hKAT-1 on IAC, famotidine, and bonactin were − 6.581, − 6.500 and − 7.730kcal/mol where Glide energies were − 29.84, − 28.391, and − 47.565kcal/mol, respectively. Bonactin is known as an antibacterial and antifungal compound being extracted from a marineStreptomycessp.Comparing tested compounds against the drug target hKAT-1, bonactin alone showed the best Glide score and Glide energy on the target protein hKAT-1.
Databáze: OpenAIRE
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