Chromatin-negative Klinefelter's syndrome with focal megalencephaly
| Autor: | Geri Lyn Luprecht, Khang-Cheng Ho, Hongyung Choi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Autopsy Neuropathology Klinefelter Syndrome Intellectual Disability Cortex (anatomy) Carcinoma medicine Humans Megalencephaly Carcinoma Small Cell Aged S syndrome Brain General Medicine medicine.disease Chromatin medicine.anatomical_structure Psychotic Disorders Sex Chromatin Neurology Neurology (clinical) Klinefelter syndrome Psychology |
| Zdroj: | Acta Neurologica Scandinavica. 62:357-367 |
| ISSN: | 1600-0404 0001-6314 |
| Popis: | At autopsy, 72-year-old white male with chromatin-negative Klinefelter's syndrome, mental retardation, psychotic behavior, and carcinoma of the lung was noted to have right unilateral focal cerebral and cerebellar megalencephaly with broad gyri, a cytoarchitectually abnormal cortex, and thickened cerebral vessels. Literature about the neuropathology of Klinefelter's syndrome and several cases of other chromosome aberrations (XYY and XO syndromes) are reviewed. These neuropathological changes are thought to be related to clinical manifestation. |
| Databáze: | OpenAIRE |
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