High Endothelial Venules of the Lymph Nodes Express Fas Ligand
| Autor: | Tuomo J. Karttunen, Johanna M. Mäkinen, Merja T. Augustin, Tuomo S. Kokkonen, Jorma Kokkonen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Fas Ligand Protein Histology Adolescent Lymphocyte High endothelial venules Biology Fas ligand 03 medical and health sciences Venules medicine Lymph node stromal cell Humans Child Lymph node Aged Membrane Glycoproteins 030102 biochemistry & molecular biology Middle Aged Fas receptor Immunohistochemistry 030104 developmental biology Lymphatic system medicine.anatomical_structure Child Preschool Female Endothelium Vascular Lymph Nodes Lymph Anatomy |
| Zdroj: | Journal of Histochemistry & Cytochemistry. 52:693-699 |
| ISSN: | 1551-5044 0022-1554 |
| Popis: | Fas (CD95, APO-1) is widely expressed on lymphatic cells, and by interacting with its natural ligand (Fas-L), Fas induces apoptosis through a complex caspase cascade. In this study we sought to survey Fas-L expression in vascular and sinusoidal structures of human reactive lymph nodes. Immunohistochemical Fas-L expression was present in all paracortical high endothelial venules (HEVs), in cells lining the marginal sinus wall, and in a few lymphocytes, but only occasionally in non-HEV vascular endothelium. In the paracortical zone over 60% of all vessels and all paracortical HEVs showed Fas-L expression, whereas in the medullary zone less than 10% of the blood vessels were stained with Fas-L. Normal vessels outside lymph nodes mostly showed no Fas-L expression. We show that in human reactive lymph nodes Fas-L expression is predominantly present in HEVs. Because the circulating lymphocytes gain entry to nodal parenchyma by transendothelial migration through HEVs, the suggested physiological importance of Fas-L expression in these vessels lies in the regulation of lymphocyte access to lymph node parencyhyma by possibly inducing Fas/Fas-L mediated apoptosis of activated Fas-expressing lymphoid cells. The Fas-L expressing cells in the marginal sinus might have a similar function for cells accessing the node in afferent lymph. |
| Databáze: | OpenAIRE |
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