A possible predictive marker of progression for hepatocellular carcinoma
| Autor: | Susan Costantini, Giovanni Colonna, Maria Grazia Volpe, Melissa Nazzaro, Michele Di Stasio, Giuseppe Castello, Miriam Polimeno, Stefania Scala |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
inorganic chemicals
Cancer Research Pathology medicine.medical_specialty chemistry.chemical_element medicine.disease_cause Gastroenterology Internal medicine Medicine Selenium binding selenium atomic absorption spectrometry Predictive marker Oncogene business.industry Cancer food and beverages Articles hepatocarcinoma prognosis medicine.disease Molecular medicine Oncology chemistry HCC marker Hepatocellular carcinoma selenium binding protein-1 business Selenium Oxidative stress |
| Zdroj: | Oncology Letters 2 (2011): 1247–1251. doi:10.3892/ol.2011.378 info:cnr-pdr/source/autori:Di Stasio M; Volpe MG; Colonna G; Nazzaro M; Polimeno M; Scala S; Castello G; Costantini S/titolo:A possible predictive marker of progression for hepatocellular carcinoma/doi:10.3892%2Fol.2011.378/rivista:Oncology Letters/anno:2011/pagina_da:1247/pagina_a:1251/intervallo_pagine:1247–1251/volume:2 |
| DOI: | 10.3892/ol.2011.378 |
| Popis: | The correlation between decreased levels of selenium and increased DNA damage and oxidative stress shows the significance of this trace element. A number of studies have provided evidence for lower serum, plasma and tissue levels of selenium in patients with various diseases and types of cancer. In this study, liver selenium concentrations were measured in tissue samples of patients with hepatocellular carcinoma (HCC) by atomic absorption spectrometry. The results showed that the selenium concentrations decreased when the malignant grade increased. Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Therefore, we suggest that the evaluation of selenium and SELENBP1 concentrations can be used for improving the prognosis of HCC. |
| Databáze: | OpenAIRE |
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