Anticoagulant drugs in noncompaction: A mandatory therapy?
| Autor: | Loredana Sutera, Luciana D'Angelo, Gabriele Di Gesaro, Magnus Baumhakel, Luca Sormani, Elisabetta Zachara, Filippo Ferrara, Fabrizio Drago, Claudia Visconti, Giovanni Corrado, Salvatore Novo, Giovanni Fazio, Indovina G, Claudio Rapezzi, Abraham Benatar, Yuksel Cavusoglu, Giuseppina Novo, Maurizio Mongiovì, Claudia Stöllberger, Ali K. Sulafa, Salvatore Pipitone, Scipione Carerj, Joseph Finsterer |
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| Přispěvatelé: | Fazio, Giovanni, Corrado, Giovanni, Zachara, Elisabetta, Rapezzi, Claudio, Sulafa, Ali K, Sutera, Loredana, Stollberger, Claudia, Sormani, Luca, Finsterer, Joseph, Benatar, Abraham, Di Gesaro, Gabriele, Visconti, Claudia, Dangelo, Luciana, Novo, Giuseppina, Mongiovi, Maurizio, Cavusoglu, Yuksel, Baumhakel, Magnu, Drago, Fabrizio, Indovina, Giuseppe, Ferrara, Filippo, Carerj, Scipione, Pipitone, Salvatore, Novo, Salvatore, FAZIO G, CORRADO G, ZACHARA E, RAPEZZI C, SULAFA AK, SUTERA L, STOLLBERGER C, SORMANI L, FINSTERER J, BENATAR A, DI GESARO G, VISCONTI C, D'ANGELO L, NOVO G, MONGIOVI M, CAVOSOGLU Y, BAUMHAKEL M, DRAGO F, INDOVINA G, FERRARA F, CARERJ S, PIPITONE S, NOVO S, CAVUSOGLU Y |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Registrie Time Factors Embolism Administration Oral Heart Ventricle Risk Factors Registries Stroke Ischemic stroke Anticoagulant Congenital cardiomyopathy General Medicine Middle Aged Anticoagulant drugs Cardiology cardiovascular system Female Anticoagulant drugs noncompaction Cardiomyopathies Cardiology and Cardiovascular Medicine Human Adult Heart Defects Congenital medicine.medical_specialty Stroke etiology Time Factor medicine.drug_class Isolated left ventricular noncompaction Heart Ventricles anticoagulant embolism ischemic stroke Internal medicine Thromboembolism medicine Humans cardiovascular diseases Thrombus Noncompaction Cardiomyopathie business.industry Risk Factor Anticoagulants Infant medicine.disease Settore MED/11 - Malattie Dell'Apparato Cardiovascolare Thrombu Left ventricular myocardium business |
| Popis: | BACKGROUND: Noncompaction of left ventricular myocardium is a rare congenital cardiomyopathy resulting from an incomplete myocardial morphogenesis that leads to the persistence of the embryonic myocardium. This condition is characterized by a thin compacted epicardial and an extremely thickened endocardial layer with prominent trabeculations and deep intertrabecular recesses. It is not clear, in noncompaction of myocardium, whether intertrabecular recesses could be responsible for thrombi formation and thromboembolic complications. METHODS: The prevalence of stroke and echocardiographic finding of thrombus was evaluated in a continuous series of 229 patients (men and women) affected by noncompaction of the left ventricular myocardium, who were included in the SIEC registry. We excluded patients affected by atrial fibrillation. RESULTS: The mean age of the patients was 49.5 years. Fifty percent of the patients were affected by a ventricular systolic dysfunction. The mean period of follow-up was 7.3 years. Only four patients had a history of ischemic stroke. A large thrombus into the left ventricular chamber was observed in a 1-year-old child affected by Behcet's disease (high risk of thrombi formation). CONCLUSION: Noncompaction of the left ventricular myocardium, by itself, does not seem to be a risk factor for stroke or embolic results, so there is no indication for oral anticoagulant therapy. © 2008 Italian Federation of Cardiology. |
| Databáze: | OpenAIRE |
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