A Rare Adult Case with Diffuse Segmental Membranous Glomerulonephritis
| Autor: | Fukuo Kondo, Kenichiro Kojima, Yoshihide Fujigaki, Shigeru Shibata, Takamasa Iwakura, Shunya Uchida, Yoshifuru Tamura, Yutaka Yamaguchi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pathology medicine.medical_specialty Kidney Glomerulus 030232 urology & nephrology Serum albumin Case Report 030204 cardiovascular system & hematology Glomerulonephritis Membranous 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine IgG subclass renal pathology Internal Medicine medicine Humans Aged Thrombospondin Creatinine Proteinuria biology medicine.diagnostic_test business.industry Receptors Phospholipase A2 adult Autoantibody Glomerulonephritis General Medicine medicine.disease Microscopy Electron chemistry Renal pathology Immunoglobulin G biology.protein secondary membranous glomerulonephritis Renal biopsy medicine.symptom membranous glomerulonephritis business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 71-year-old man with hypertension and diabetes mellitus presented with proteinuria. Laboratory data showed proteinuria of 3.1 g/g creatinine, serum albumin of 3.5 g/dL and serum creatinine of 1.03 mg/dL without autoantibodies. A renal biopsy revealed segmental granular IgG depositions on glomerular capillary walls. Electron microscopy showed segmentally subepithelial, intramembranous and mesangial deposits. Diffuse segmental membranous glomerulonephritis (MGN) was diagnosed with only IgG1 deposition and without M-type phospholipase A2 receptor or thrombospondin type-1 domain-containing 7A staining, suggesting secondary MGN with an unknown target antigen in immune deposits. Physicians should keep in mind the existence of segmental MGN to better understand the clinicopathological characteristics. |
| Databáze: | OpenAIRE |
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