Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease
| Autor: | J. E. Rees, C. D. Marsden, R.C.H Baxter, J. D. Parkes |
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| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Levodopa Movement disorders Parkinson's disease Eye Movements Trihexyphenidyl Xerostomia Pharmacotherapy Amantadine medicine Edema Humans Aged Movement Disorders Parkinsonism digestive oral and skin physiology Parkinson Disease Articles Middle Aged Comparative trial medicine.disease Dihydroxyphenylalanine nervous system diseases Parkinson Disease Postencephalitic Psychiatry and Mental health Anesthesia Physical therapy Drug Therapy Combination Female Surgery Neurology (clinical) medicine.symptom Cognition Disorders Psychology medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 37:422-426 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.37.4.422 |
| Popis: | Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months. |
| Databáze: | OpenAIRE |
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