Brain Docosahexaenoate Accretion in Fetal Baboons: Bioequivalence of Dietary α-Linolenic and Docosahexaenoic Acids
| Autor: | Rebecca C Sheaff Greiner, J. Thomas Brenna, Peter W. Nathanielsz, James A. Winter |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Linolenic acid Bioequivalence Biology Cerebro Retina Embryonic and Fetal Development chemistry.chemical_compound Pregnancy Internal medicine medicine Animals chemistry.chemical_classification Fetus Fatty Acids Brain alpha-Linolenic Acid Fatty acid Retinal Metabolism Dietary Fats Endocrinology Liver Therapeutic Equivalency Biochemistry chemistry Docosahexaenoic acid Pediatrics Perinatology and Child Health Female Papio |
| Zdroj: | Pediatric Research. 42:826-834 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199712000-00018 |
| Popis: | The dietary bioequivalence during the brain growth spurt of alpha-linolenic (LNA) and docosahexaenoic acids (DHA) as substrates for brain and retinal n-3 fatty acid accretion is reported for the fetal baboons, whose mothers consumed a long chain polyunsaturate-free diet with a n-6/n-3 ratio of 10:1. Pregnant baboons received i.v. doses of U-13C-labeled fatty acids (LNA or DHA), plasma was collected from mother and fetus, and fetal brain (occipital cortex), retina, and liver were analyzed at various times post-dose. Fetal brain DHA plateaued 15-35 d post-dose with 1.6% of the preformed [U-13C-]DHA dose recovered in the brain. In contrast, LNA-derived DHA accretion also plateaued but was 20-fold lower. Liver and retinal results were of the same order of magnitude, but showed evidence of peaks and decline. Conversion products to n-3 long chain polyunsaturate were observed in the maternal circulation at 1 h after administration, as was transfer of both fatty acids to the fetus. From these measurements we estimate that a dietary level of about 0.45% of energy as LNA is sufficient to meet the requirements of the growing fetal brain, whereas 0.03% of energy as DHA would suffice. These data are the first direct measurements of the bioequivalence of DHA and LNA in developing primates and imply that n-3 fatty acid requirements for the developing fetal brain can be met by attainable dietary LNA for diets low in long chain polyunsaturates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|