Cadmium induced limb defects in mice: strain associated differences in sensitivity
| Autor: | M. W. Layton, W. M. Layton |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
C57BL/6
Male Embryology medicine.medical_specialty animal structures Health Toxicology and Mutagenesis Limb Deformities Congenital chemistry.chemical_element Mice Inbred Strains Hindlimb Biology Toxicology BALB/c Mice Inbred strain Pregnancy Internal medicine Forelimb Testis medicine Animals Cadmium Fetus Dose-Response Relationship Drug Abnormalities Drug-Induced biology.organism_classification Acetazolamide medicine.anatomical_structure Endocrinology chemistry Genes Immunology Female Developmental Biology medicine.drug |
| Zdroj: | Teratology. 19(2) |
| ISSN: | 0040-3709 |
| Popis: | Cadmium (CdSO4) was given ip on day 9 at 12 or 24 mumol/kg to pregnant CD-1 (non-inbred) mice. Fetuses showed malformations of the limbs, face, trunk, and tail. There was a statistically significant relationship between the dose of cadmium and the malformation rate. Cadmium (12 mumol/kg ip on day 9) was then given to mice of six inbred strains three of which (A/J, BALB/cJ, and C57BL6J) carry a gene cdm for resistance to cadmium-induced testicular damage, and three strains (AKR/J, CBA/J, and DBA/2J) which do not. Paradoxically, the three strains resistant to cadmium induced testicular damage were significantly more sensitive to its teratogenic effects than were the other three strains. In all inbred strains most malformations involved the limbs. All forelimb defects found in inbred or non-inbred cadmium treated mice were postaxial and indistinguishable from those produced by acetazolamide in mice. The remarkable similarity of the cadmium- and acetazolamide-induced forelimb malformations may be a reflection of the limited number of ways that a rodent forelimb can react to a teratogenic insult. The hindlimb defects were all preaxial. |
| Databáze: | OpenAIRE |
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