The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation
| Autor: | Freek J. Zijlstra, H.J.M. van Hoof, I.M. Garrelds, H.P. Voss, Aalt Bast, L. van Bree, J. A. M. A. Dormans |
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| Přispěvatelé: | Medicinal chemistry, Internal Medicine |
| Rok vydání: | 1997 |
| Předmět: |
Ozone
business.industry Immunology Albumin Inflammation Cell Biology Pharmacology Guinea pig chemistry.chemical_compound chemistry Acute exposure Toxicity medicine lcsh:Pathology lipids (amino acids peptides and proteins) Ozone exposure medicine.symptom business SDG 6 - Clean Water and Sanitation Lung function lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, 6, 355-361. Hindawi Publishing Corporation Mediators of Inflammation, 355-361. Hindawi Publishing Corporation ISSUE=6;STARTPAGE=355;ENDPAGE=361;ISSN=0962-9351;TITLE=Mediators of Inflammation Mediators of Inflammation, Vol 6, Iss 5-6, Pp 355-361 (1997) van Hoof, H J M, Zijlstra, F J, Voss, H P, Garrelds, I M, Dormans, J A M A, van Bree, L & Bast, A 1997, ' The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation. ', Mediators of Inflammation, vol. 6, pp. 355-361 . https://doi.org/10.1080/09629359791497 |
| ISSN: | 0962-9351 |
| DOI: | 10.1080/09629359791497 |
| Popis: | The observed effects after ozone exposure strongly depend on ozone concentration and exposure time. We hypothesized that depending on the O3exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm 2 h) for studying the oxidant damage and an exposure (1 ppm 12 h) where an inflammatory component is also probably involved. We measured LDH activity and protein and albumin exudation as markers for cellular damage. After the acute exposure an increase in LDH activity was measured and after exposure to 1 ppm ozone for 12 h the exudation of protein and albumin was also enhanced. The histological examinations showed a neutrophilic inflammatory response only after exposure to 1 ppm ozone for 12 h. The acute exposure protocol resulted in an increased release of PGE2, PGD2, PGF2αand 6-ketoPGF1αwhereas exposure to 1 ppm ozone for 12 h led to an additional release of LTB4. No effects were measured on the release of TxB2and LTC4/D4/E4. These changed amounts of eicosanoids will probably contribute to the ozone-induced lung function changes. |
| Databáze: | OpenAIRE |
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