Identification of Potential Interaction Networks Using Sequence-Based Searches for Conserved Protein-Protein Interactions or 'Interologs'
| Autor: | Marc Vidal, Philippe Vaglio, Jérôme Reboul, Brian P. Davis, Hui Ge, James I. Garrels, Sylvie Vincent, Lisa Matthews |
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| Rok vydání: | 2001 |
| Předmět: |
Whole genome sequencing
Genetics ved/biology ved/biology.organism_classification_rank.species Proteins A protein Computational biology Biology Protein–protein interaction Fungal Proteins Crosstalk (biology) Protein Interaction Mapping Methods Animals Amino Acid Sequence Caenorhabditis elegans Proteins Databases Protein Model organism Conserved Sequence Genetics (clinical) Protein Interaction Map |
| Zdroj: | Genome Research. 11:2120-2126 |
| ISSN: | 1549-5469 1088-9051 |
| DOI: | 10.1101/gr.205301 |
| Popis: | Protein interaction maps have provided insight into the relationships among the predicted proteins of model organisms for which a genome sequence is available. These maps have been useful in generating potential interaction networks, which have confirmed the existence of known complexes and pathways and have suggested the existence of new complexes and or crosstalk between previously unlinked pathways. However, the generation of such maps is costly and labor intensive. Here, we investigate the extent to which a protein interaction map generated in one species can be used to predict interactions in another species. |
| Databáze: | OpenAIRE |
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