Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients
| Autor: | Michael G. Burton, Susana Chavez-Bueno, Peter Johnson, Christine Allen, Kevin C. Farmer, Emily C. Benefield, Tracy M. Hagemann |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Creatinine business.industry Clinical Investigations Acute kidney injury Retrospective cohort study 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine medicine.disease Surgery 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics chemistry Cardiothoracic surgery Anesthesia Pediatrics Perinatology and Child Health Medicine Vancomycin Pharmacology (medical) 030212 general & internal medicine Dosing business medicine.drug |
| Zdroj: | The Journal of Pediatric Pharmacology and Therapeutics. 21:66-74 |
| ISSN: | 1551-6776 |
| DOI: | 10.5863/1551-6776-21.1.66 |
| Popis: | OBJECTIVES: This study compared vancomycin trough concentrations and pharmacokinetic parameters in pediatric cardiothoracic surgery (CTS) patients versus those in controls receiving 20 mg/kg/dose, intravenously, every 8 hours. METHODS: A retrospective study was conducted in children RESULTS: Twenty-seven patients in each group were evaluated. Mean trough concentrations were significantly different between groups (CTS: 18.4 mg/L; control: 8.8 mg/L; p < 0.01). Vancomycin-associated acute kidney injury AKI was significantly higher in the CTS group than in controls (25.9% versus 0%, respectively, p CONCLUSIONS: Vancomycin dosage of 20 mg/kg/dose intravenously every 8 hours achieved significantly higher trough concentrations in CTS patients than in controls. Pharmacokinetic parameters were highly variable in CTS patients, indicating more individualization of dosage is needed. A future prospective study is needed to determine whether the revised dosage projections achieve the AUC:MIC target and to determine whether these regimens are associated with less vancomycin-associated AKI. |
| Databáze: | OpenAIRE |
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