Epidemiological Link between Gastric Disease and Polymorphisms in VacA and CagA
| Autor: | Sungil Jang, Young Min Joo, Jeong Heon Cha, In Sik Chung, D. Scott Merrell, Cara H. Olsen, Yun-Jung Yoo, Kathleen R. Jones |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
DNA Bacterial Male Microbiology (medical) Peptic Ulcer medicine.medical_specialty Adolescent Genotype Virulence Factors Molecular Sequence Data Helicobacter Infections Young Adult Bacterial Proteins Gene Frequency Stomach Neoplasms Molecular genetics Genetic variation medicine Animals Humans CagA Allele Allele frequency Aged Aged 80 and over Genetics Antigens Bacterial Korea Helicobacter pylori biology Bacteriology Sequence Analysis DNA Middle Aged bacterial infections and mycoses biology.organism_classification digestive system diseases Gastritis Immunology Female medicine.symptom |
| Zdroj: | Journal of Clinical Microbiology. 48:559-567 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.01501-09 |
| Popis: | Gastritis, peptic ulcer disease, and gastric cancer are a few of the diverse disease manifestations that have been shown to be associated with infection by Helicobacter pylori . Why some individuals develop more severe forms of disease remains largely unknown. In this study, 225 South Korean strains were genotyped for vacA and then analyzed to determine if particular genotypes varied across disease state, sex, or cagA allele. Of these strains, 206 strains carried an s1/i1/m1 allele, 11 strains carried an s1/i1/m2 allele, and 8 strains carried an s1/i2/m2 allele. By using Fisher's exact test, a statistical association between variations in the cagA and vacA alleles was identified ( P = 0.0007), and by using log linear modeling, this variation was shown to affect the severity of disease outcome ( P = 0.027). Additionally, we present evidence that variation within the middle region of VacA contributes significantly to the distribution of vacA alleles across gender ( P = 0.008) as well as the association with disease outcome ( P = 0.011). In this South Korean population, the majority of H. pylori strains carry the vacA s1/i1/m1 allele and the CagA EPIYA-ABD allele. These facts may contribute to the high incidence of gastric maladies, including gastric cancer. |
| Databáze: | OpenAIRE |
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