Host Genetic Control of the Oral Microbiome in Health and Disease
| Autor: | Jeffrey M. Craig, Karen E. Nelson, Andres Gomez, Richard Saffery, Rohith Kodukula, Josh L. Espinoza, Pamela Leong, Jason M. Inman, Christopher L. Dupont, Manolito Torralba, Sarah K. Highlander, Michelle Bockmann, Claire Kuelbs, Marcus B. Jones, Toby Hughes, Derek M. Harkins |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Genotype Twins Disease Biology Dental Caries Microbiology Article 03 medical and health sciences 0302 clinical medicine Virology Humans Genetic Predisposition to Disease Microbiome Child Ecosystem Phylogeny Genetics Mouth Bacteria Host (biology) Microbiota Human microbiome Age Factors 030206 dentistry Phenotype 030104 developmental biology Parasitology Child Preschool Female Oral Microbiome |
| Zdroj: | Cell hostmicrobe. 22(3) |
| ISSN: | 1934-6069 |
| Popis: | Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged five to eleven. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors. |
| Databáze: | OpenAIRE |
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