Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: and experimental study in rats
| Autor: | Udo P. Schmiedl, R C Brasch, M D Ogan, Michael E. Moseley |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy animal diseases media_common.quotation_subject Serum albumin Contrast Media Vascular permeability Albumin-Gd-DTPA chemistry.chemical_compound Internal medicine Mole Extracellular fluid medicine Distribution (pharmacology) Contrast (vision) Animals Radiology Nuclear Medicine and imaging cardiovascular diseases media_common biology business.industry Pentetic acid Serum Albumin Bovine General Medicine respiratory system Pentetic Acid Image Enhancement Surgery Rats Endocrinology chemistry Subtraction Technique cardiovascular system biology.protein business circulatory and respiratory physiology |
| Zdroj: | AJR. American journal of roentgenology. 147(6) |
| ISSN: | 0361-803X |
| Popis: | Albumin-(gadolinium-diethylenetriaminepentaacetic acid), albumin-(Gd-DTPA), a macromolecular MR contrast agent designed for intravascular distribution, was compared with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), an extracellular fluid agent, for imaging characteristics in normal rats at 2.0 T. Albumin-(Gd-DTPA) produced larger-intensity increases in myocardium (125%), liver (114%), and brain (21%), at a dose of 0.062 mmol Gd/kg than did Gd-DTPA at a dose of 0.2 mmol/kg. The duration and pattern of enhancement differed between the two compounds; the enhancement with albumin-(Gd-DTPA) persisted at relatively constant levels from 2 min to 1 hr. The Gd-DTPA tissue enhancement peaked at 2 min and had virtually disappeared at 60 min. Gd-DTPA better enhanced subcutaneous tissues, presumably because of capillary permeability and enhancement of the abundant extracellular fluid space. When albumin-(Gd-DTPA) is used, the strong persistent enhancement of the microvascular compartment is well demonstrated on subtracted images and supports potential application of albumin-(Gd-DTPA) for blood-volume and perfusion-dependent contrast enhancement of myocardium, liver, and brain. |
| Databáze: | OpenAIRE |
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