Maternal prepregancy BMI and lipid profile during early pregnancy are independently associated with offspring's body composition at age 5-6 years: the ABCD study

Autor: Adriëtte J. J. M. Oostvogels, Manon van Eijsden, Marloes Vermeulen, Tessa J. Roseboom, Tanja G. M. Vrijkotte, Tommy L S Visscher, Marcel Th. B. Twickler, Maaike G. J. Gademan
Přispěvatelé: Public and occupational health, Graduate School, APH - Amsterdam Public Health, ARD - Amsterdam Reproduction and Development, Epidemiology and Data Science, Obstetrics and Gynaecology, Other departments, Prevention and Public Health, EMGO+ - Lifestyle, Overweight and Diabetes
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Epidemiology
Maternal Health
lcsh:Medicine
Overweight
Fatty Acids
Nonesterified
Biochemistry
Pediatrics
Body Mass Index
Cohort Studies
Child Development
Pregnancy
Risk Factors
Medicine and Health Sciences
Birth Weight
Public and Occupational Health
lcsh:Science
Pediatric Epidemiology
Child
Adiposity
Netherlands
Multidisciplinary
medicine.diagnostic_test
Child Health
Gestational age
Obstetrics and Gynecology
SDG 10 - Reduced Inequalities
Lipids
Cholesterol
Research Design
Child
Preschool
Body Composition
Regression Analysis
Female
medicine.symptom
Engineering sciences. Technology
Research Article
Adult
medicine.medical_specialty
Offspring
Clinical Research Design
Birth weight
Mothers
Gestational Age
Research and Analysis Methods
Childhood obesity
Internal medicine
medicine
Humans
Triglycerides
Apolipoproteins B
Survey Research
business.industry
lcsh:R
Biology and Life Sciences
medicine.disease
Endocrinology
Metabolism
Survey Methods
Women's Health
lcsh:Q
business
Lipid profile
Body mass index
Zdroj: PLoS ONE, 9(4). Public Library of Science
PLoS ONE, 9(4):e94594. Public Library of Science
PLoS ONE
Gademan, M G J, Vermeulen, M, Oostvogels, A J J M, Roseboom, T J, Visscher, T L S, Eijsden, M, Twickler, M T B & Vrijkotte, T G M 2014, ' Maternal Prepregancy BMI and Lipid Profile during Early Pregnancy Are Independently Associated with Offspring's Body Composition at Age 5-6 Years: The ABCD Study ', PLoS ONE, vol. 9, no. 4, e94594 . https://doi.org/10.1371/journal.pone.0094594
PLoS ONE, Vol 9, Iss 4, p e94594 (2014)
ISSN: 1932-6203
Popis: Background: There is growing evidence that disturbances in maternal metabolism and, subsequently, intrauterine conditions affect foetal metabolism. Whether this has metabolic consequences in offspring later in life is not fully elucidated. We investigated whether maternal pre-pregnancy body mass index (pBMI) is associated with offspring's adiposity at age 5-6 years and whether this association is mediated by the mother's lipid profile during early pregnancy. Methods: Data were derived from a multi-ethnic birth cohort, the Amsterdam Born Children and their Development (ABCD) study (inclusion 2003-2004). During early gestation mothers completed a questionnaire during pregnancy (pBMI) and random non-fasting blood samples were analysed for total cholesterol (TC), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and total free fatty acids (FFA) in early gestation. At age 5-6 years, child's BMI, waist-to-height-ratio (WHtR) and fat% were assessed. Results: Only non-diabetic mothers with at term-born children were included(n = 1727). Of all women, 15.1% were overweight(BMI: 25-29.9 kg/m2) and 4.3% were obese(BMI >= 30 kg/m2). After adjustments for confounders, every unit increase in pBMI was linearly associated with various offspring variables: BMI(beta 0.10; 95% CI 0.08-0.12), WHtR* 100(beta 0.13; 95% CI 0.09-0.17), fat%(beta 0.21; 95% CI 0.13-0.29) and increased risk for overweight(OR: 1.15; 95% CI 1.10-1.20). No convincing proof for mediation by maternal lipid profile during early gestation was found. Moreover, maternal FFA was associated with the child's fat percentage, BMI and risk for overweight. Maternal ApoB and TC were positively associated with the offspring's fat percentage and maternal TG was positively associated with their children's WHtR. Conclusions: Both pBMI and maternal lipids during early pregnancy are independently related to offspring adiposity.
Databáze: OpenAIRE
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