Inhibition of the Late Phase Reaction to Anti-IgE by Previous Mast Cell Activation with Compound 48/80
| Autor: | Reidar Grönneberg |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Allergy Immunology Human skin Immunoglobulin E chemistry.chemical_compound Late phase medicine Humans p-Methoxy-N-methylphenethylamine Immunology and Allergy Hypersensitivity Delayed Mast Cells Skin Tests biology Chemistry Middle Aged Compound 48/80 Mast cell medicine.disease Molecular biology Antibodies Anti-Idiotypic medicine.anatomical_structure biology.protein Liberation Female Histamine |
| Zdroj: | Allergy. 39:119-123 |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | The concept of an obligate association between mast cell activation and development of a late phase reaction (LPR) to various agents in human skin was further elucidated. Skin sites were treated four times at 24 h intervals with non-LPR-inducing doses of the histamine liberator compound 48/80 in 10 volunteers. The previously compound 48/80-challenged sites responded with an approximately 40% attenuated early response (P less than 0.01) and a 70% reduction of the LPR (P less than 0.001) to subsequently injected anti-IgE as compared with simultaneous reactions at control sites. The data suggest that mediators from the cutaneous mast cells are necessary for the final expression of an LPR. |
| Databáze: | OpenAIRE |
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