Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism
| Autor: | Jonathon M Brown, Michael McIntosh, Mary E. Evans |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics integumentary system Endocrinology Diabetes and Metabolism Conjugated linoleic acid Linoleic acid Clinical Biochemistry food and beverages Fatty acid Lipid metabolism Metabolism Biology Biochemistry chemistry.chemical_compound Endocrinology chemistry Internal medicine Adipocyte medicine Lipolysis lipids (amino acids peptides and proteins) Molecular Biology Beta oxidation |
| Zdroj: | The Journal of nutritional biochemistry. 13(9) |
| ISSN: | 1873-4847 |
| Popis: | Isomers of conjugated linoleic acid (CLA), unsaturated fatty acids found in ruminant meats and dairy products, have been shown to reduce adiposity and alter lipid metabolism in animal, human, and cell culture studies. In particular, dietary CLA decreases body fat and increases lean body mass in certain rodents, chickens, and pigs, depending on the isomer, dose, and duration of treatment. However, the effects of CLA on human adiposity are conflicting because these studies have used different mixtures and levels of CLA isomers and diverse subject populations. Potential antiobesity mechanisms of CLA include decreased preadipocyte proliferation and differentiation into mature adipocytes, decreased fatty acid and triglyceride synthesis, and increased energy expenditure, lipolysis, and fatty acid oxidation. This review will address the current research on CLA's effects on human and animal adiposity and lipid metabolism as well as potential mechanism(s) responsible for CLA's antiobesity properties. |
| Databáze: | OpenAIRE |
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