Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)
| Autor: | Uilson Pereira dos Santos, Jaqueline Ferreira Campos, Kely de Picoli Souza, Edgar J. Paredes-Gamero, Luis Fernando Benitez Macorini, Claudia Andrea Lima Cardoso, José Benedito Perrella Balestieri, Adriana Mary Mestriner Felipe de Melo, Edson Lucas dos Santos |
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| Rok vydání: | 2014 |
| Předmět: |
Erythrocytes
Antioxidant Stingless bee medicine.medical_treatment Antineoplastic Agents Microbial Sensitivity Tests Toxicology Antioxidants Propolis Lipid peroxidation Terpene chemistry.chemical_compound Anti-Infective Agents medicine Animals Humans Candida albicans biology Traditional medicine General Medicine Bees biology.organism_classification Antimicrobial Terpenoid chemistry Biochemistry K562 Cells Food Science |
| Zdroj: | Food and Chemical Toxicology. 65:374-380 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2014.01.008 |
| Popis: | Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. The chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. The EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. The EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation. |
| Databáze: | OpenAIRE |
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