Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes
Autor: | Nicholas T. Broskey, Charmaine S. Tam, Leanne M. Redman, Elizabeth F. Sutton, Eric Ravussin, Abby D. Altazan, Jeffrey H. Burton |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
endocrine system diseases Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue 030209 endocrinology & metabolism lcsh:TX341-641 Clinical nutrition Type 2 diabetes Carbohydrate metabolism 03 medical and health sciences 0302 clinical medicine Insulin resistance Metabolic flexibility Internal medicine medicine lcsh:RC620-627 Polycystic ovary syndrome 030219 obstetrics & reproductive medicine Nutrition and Dietetics Free androgen index business.industry Substrate oxidation Hyperinsulinemic euglycemic clamp Research nutritional and metabolic diseases medicine.disease Polycystic ovary Obesity lcsh:Nutritional diseases. Deficiency diseases Endocrinology business lcsh:Nutrition. Foods and food supply |
Zdroj: | Nutrition & Metabolism, Vol 15, Iss 1, Pp 1-9 (2018) Nutrition & Metabolism Nutrition & metabolism, 15:75 |
ISSN: | 1743-7075 |
Popis: | BACKGROUND: An ability to switch between primarily oxidizing fat in the fasted state to carbohydrate in the fed state, termed metabolic flexibility, is associated with insulin sensitivity. Metabolic flexibility has been explored previously in women with polycystic ovary syndrome (PCOS), yet the independent or synergistic contributions of androgen excess and/or insulin resistance is not yet known. Therefore, the purpose of this article was to characterize metabolic flexibility in women with PCOS compared to women of normal BMI, obesity, or type 2 diabetes (T2DM). METHODS: Eighty-six weight-stable women; thirty with either PCOS (n = 30), or fifty-six with obesity (n = 12), T2DM (n = 27), or normal BMI (n = 17) underwent a hyperinsulinemic euglycemic clamp and indirect calorimetry to measure insulin sensitivity and substrate oxidation via indirect calorimetry, respectively. RESULTS: All analyses were adjusted for differences in age, ethnicity, and BMI between groups. Women with PCOS were less metabolically flexible compared to healthy women with obesity (p |
Databáze: | OpenAIRE |
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