Association of renal tubular hyaline droplets with lymphoma in CD-1 mice
| Autor: | Malgorzata Brej, Leland Wayne Dochterman, Amanda L. Niquette, Joshua H. Decker |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Hyalin Lymphoma Carcinogenicity Tests Mice Transgenic Biology Histiocytic sarcoma Toxicology Kidney Pathology and Forensic Medicine Mice Necrosis medicine Chronic Progressive Nephropathy Animals Molecular Biology Hyaline Kidney metabolism Cell Biology medicine.disease CD79A Immunohistochemistry Kidney Neoplasms Disease Models Animal medicine.anatomical_structure Kidney Tubules Female Histiocytic Sarcoma |
| Zdroj: | Toxicologic pathology. 40(4) |
| ISSN: | 1533-1601 |
| Popis: | In mice, hyaline droplets in renal proximal tubules have been associated with histiocytic sarcoma but have not been reported with lymphoma. Tissues from CD-1 mice in a 2-year carcinogenicity bioassay were examined microscopically. Twenty-five mice with hyaline droplets in renal tubules were identified. Immunohistochemistry to detect IgA, IgG, IgM, lysozyme, albumin, CD3, and CD79a was performed on kidneys of 21 affected mice. Hyaline droplets were present in the kidneys of 11 mice with lymphoma (1 male, 10 female), of which 1 female also had histiocytic sarcoma. Hyaline droplets were also present in 7 other mice with histiocytic sarcoma, 2 with chronic progressive nephropathy, 3 with renal cortical tubular necrosis, and 2 with granulocytic leukemia. Five of the 11 lymphomas were CD3+, indicating a T lymphocyte origin. Hyaline droplets in mice with lymphoma did not stain for IgA, IgG, or IgM, except in one questionable case. Results of other immunohistochemical stains were inconclusive. Although the droplet composition could not be determined immunohistochemically, the study findings indicate that renal tubular hyaline droplets may be associated with lymphoma in mice. |
| Databáze: | OpenAIRE |
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