Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort

Autor: Nils-Halvdan Morken, Rolv T. Lie, Kim Christian Danielsson, Ingrid Borthen, Nils Erik Gilhus
Jazyk: angličtina
Rok vydání: 2019
Předmět:
medicine.medical_treatment
Maternal Health
Blood Pressure
Vascular Medicine
Epidural Block
Epilepsy
Labor and Delivery
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Anesthesiology
Medicine and Health Sciences
Childbirth
Anesthesia
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Pharmaceutics
Norway
Obstetrics and Gynecology
Neurology
Cohort
Hypertension
Medicine
Premature Birth
Female
Cohort study
Research Article
Adult
medicine.medical_specialty
Science
Preterm Birth
03 medical and health sciences
Drug Therapy
Hypertensive Disorders in Pregnancy
medicine
Humans
Caesarean section
business.industry
Cesarean Section
Postpartum Hemorrhage
Parturition
medicine.disease
Preeclampsia
Pregnancy Complications
Relative risk
Birth
Small for gestational age
Women's Health
sense organs
Local and Regional Anesthesia
business
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0225334 (2019)
PLOS ONE
ISSN: 1932-6203
Popis: ObjectiveObstetric trends show changes in complication rates and maternal characteristics such as caesarean section, induced labour, and maternal age. To what degree such general time trends and changing patterns of antiepileptic drug use influence pregnancies of women with epilepsy (WWE) is unknown. Our aim was to describe changes in maternal characteristics and obstetric complications in WWE over time, and to assess changes in complication risks in WWE relative to women without epilepsy.MethodsThis was a nationwide cohort study of all first births in the Medical Birth Registry of Norway, 1999-2016. We estimated maternal characteristics, complication rates, and risks for WWE compared to women without epilepsy. Main maternal outcome measures were hypertensive disorders, bleeding in pregnancy, induction of labour, caesarean section, postpartum hemorrhage, preterm birth, small for gestational age, and epidural analgesia. Time trends were analyzed by logistic regression and comparisons made with interaction analyses.Results426 347 first births were analyzed, and 3077 (0.7%) women had epilepsy. In WWE there was an increase in proportions of induced labour (pConclusionsDuring 1999-2016 there were important changes in maternal characteristics and complication rates among WWE. However, outcome risks for WWE relative to women without epilepsy did not change despite changes in antiepileptic drug use patterns. The relative risk of severe preeclampsia increased in women with epilepsy.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje