Anti-inflammatory effects of sacral nerve stimulation: a novel spinal afferent and vagal efferent pathway
| Autor: | Lei Tu, Jieyun Yin, Payam Gharibani, Nina Zhang, Jiande Dz Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Sacrum medicine.medical_specialty animal structures Physiology Efferent medicine.medical_treatment Efferent Pathways Efferent nerve Proinflammatory cytokine Rats Sprague-Dawley 03 medical and health sciences Neural Pathway 0302 clinical medicine Physiology (medical) Internal medicine medicine Animals Efferent Pathway Inflammation Hepatology business.industry Gastroenterology Neurectomy Vagus Nerve Colitis Spinal cord Rats Spinal Nerves 030104 developmental biology Endocrinology medicine.anatomical_structure Trinitrobenzenesulfonic Acid business 030217 neurology & neurosurgery Acetylcholine medicine.drug |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 318:G624-G634 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.00330.2019 |
| Popis: | Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study was to investigate whether the SNS anti-inflammatory effect is mediated via the local sacral splanchnic nerve or the spinal afferent-vagal efferent-colon pathway. Under general anesthesia, rats were administrated with TNBS intrarectally, and bipolar SNS electrodes were implanted unilaterally at S3. The sacral and vagal nerves were severed at different locations for the assessment of the neural pathway. SNS for 10 days improved colonic inflammation only in groups with intact afferent sacral nerve and vagus efferent nerve. SNS markedly increased acetylcholine and anti-inflammatory cytokines (IL-10) and decreased myeloperoxidase and proinflammatory cytokines (IL-2, IL-17A, and TNF-α) in colon tissues. SNS increased the number of c-fos-positive cells in the brain stem and normalized vagal activity measured by spectral analysis of heart rate variability. SNS exerts an anti-inflammatory effect on TNBS-induced colitis by enhancing vagal activity mediated mainly via the spinal afferent-brain stem-vagal efferent-colon pathway. NEW & NOTEWORTHY Our findings support that there is a possible sacral afferent-vagal efferent pathway that can transmit sacral nerve stimulation to the colon tissue. Sacral nerve stimulation can be carried out by spinal cord afferent to the brain stem and then by the vagal nerve (efferent) to the target organ. |
| Databáze: | OpenAIRE |
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