Cerebellar transcranial direct current stimulation modulates the fMRI signal in the cerebellar nuclei in a simple motor task

Autor: Oliver Kraff, Michael A. Nitsche, Sophia Göricke, Thomas M. Ernst, Dagmar Timmann, Markus Thürling, Maria R. Stefanescu, Michael Küper, Jahan Saeed Mallick
Rok vydání: 2016
Předmět:
Adult
Male
Cerebellum
medicine.medical_treatment
Dentate nucleus
Biophysics
Medizin
Stimulation
Transcranial Direct Current Stimulation
050105 experimental psychology
tDCS
lcsh:RC321-571
03 medical and health sciences
Cerebellar Cortex
Young Adult
0302 clinical medicine
Medicine
Humans
0501 psychology and cognitive sciences
Finger tapping
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Transcranial direct-current stimulation
medicine.diagnostic_test
business.industry
General Neuroscience
05 social sciences
fMRI
Magnetic Resonance Imaging
medicine.anatomical_structure
Cerebellar Nuclei
Disinhibition
Motor Skills
Cerebellar cortex
Female
Neurology (clinical)
medicine.symptom
business
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Psychomotor Performance
Zdroj: Brain Stimulation, Vol 12, Iss 5, Pp 1169-1176 (2019)
ISSN: 1876-4754
Popis: Background In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. J Neurosci 29, 9115–9122) showed that cerebellar transcranial direct current stimulation (ctDCS) alters cerebellar-M1 connectivity. This effect has been explained by ctDCS-related changes of excitability of the cerebellar cortex with consecutive modulation of its main output, the dentate-thalamo-cortical pathway. Objectives The aim of this functional magnetic resonance imaging (fMRI) study was to provide evidence that cathodal ctDCS decreases the activity of the cerebellar cortex, resulting in increased activity of the cerebellar nuclei, whereas anodal ctDCS has the opposite effect. Methods A total of 48 participants (female/male: 23/25, age: 23.8 ± 4.1yrs., mean ± standard deviation) performed a finger tapping task with the right hand in a 3T MRI scanner. Functional MR images were acquired prior, during and after tDCS of the right cerebellum. Participants were assigned randomly to anodal, cathodal or sham ctDCS. Results No significant difference of cerebellar cortical activation was found after comparing the three modes of stimulation. On the level of the dentate nuclei, however, a significant increase of activation was detected during and after cathodal stimulation. Furthermore, dentate nuclei activation was suppressed on a trend level following anodal stimulation. Conclusions The present findings support the hypothesis that cathodal ctDCS leads to a disinhibition of the dentate nucleus, whereas anodal ctDCS may have the opposite effect.
Databáze: OpenAIRE
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