Acute renal failure and severe thrombocytopenia associated with metamizole
| Autor: | R. Enríquez, Alberto Romero, Sirvent Ae, F Amorós, Maria Dolores Redondo-Pachon, Isabel Millán |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Drug
Male medicine.medical_specialty media_common.quotation_subject Dipyrone Hemodynamics lcsh:Medicine Gastroenterology Severity of Illness Index Internal medicine Severity of illness medicine Humans Intensive care medicine Adverse effect Acute tubulointerstitial nephritis Glucocorticoids Acute tubular necrosis media_common Aged business.industry lcsh:R Anti-Inflammatory Agents Non-Steroidal General Medicine Acute Kidney Injury medicine.disease Metamizole Thrombocytopenia Severe thrombocytopenia Treatment Outcome business medicine.drug |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 25, Iss 1, Pp 121-125 (2014) |
| ISSN: | 1319-2442 |
| Popis: | Metamizole or dipyrone is a pyrazolone derivative that belongs to the non-steroidal anti-inflammatory drugs. Its main side-effect is hematological toxicity. Thrombocytopenia due to metamizole is rare and is usually associated with the involvement of the two other blood series. Drug-induced thrombocytopenia is more frequently related to immune mechanisms, and the diag-nosis is still largely made by exclusion of other causes and by correlation of timing of thrombocytopenia with the administration of drug. Metamizole may cause acute renal failure due to hemodynamic renal failure/acute tubular necrosis and/or acute tubulointerstitial nephritis. We report a case of acute renal failure and severe thrombocytopenia after metamizole. As far as we know, this combination of adverse effects from this drug has not been reported previously. |
| Databáze: | OpenAIRE |
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