Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease

Autor: Coralie de Hemptinne, Randy Perrone, Marta San Luciano, Nick B. Galifianakis, Gregory A. Worrell, Robert Wilt, Ian O. Bledsoe, Paul S. Larson, Vaclav Kremen, Timothy J. Denison, Roee Gilron, Maria S. Yaroshinsky, Sarah S. Wang, Doris D. Wang, Heather E. Dawes, Simon Little, Jill L. Ostrem, David A. Borton, Caroline A. Racine, Philip A. Starr
Rok vydání: 2021
Předmět:
Male
Aging
Parkinson's disease
Deep Brain Stimulation
medicine.medical_treatment
Neurodegenerative
Applied Microbiology and Biotechnology
0302 clinical medicine
Basal ganglia
Assistive Technology
0303 health sciences
Parkinson's Disease
Rehabilitation
Motor Cortex
Parkinson Disease
Middle Aged
Adaptation
Physiological
Neuromodulation (medicine)
medicine.anatomical_structure
Neurological
Molecular Medicine
Female
Wireless Technology
Biotechnology
Neural decoding
Motor cortex
Adult
Deep brain stimulation
Physiological
Movement
1.1 Normal biological development and functioning
Biomedical Engineering
Bioengineering
Article
Wearable Electronic Devices
03 medical and health sciences
Underpinning research
Clinical Research
Behavioral and Social Science
medicine
Humans
Adaptation
030304 developmental biology
Brain–computer interface
business.industry
Neurosciences
Neurophysiology
medicine.disease
Neurophysiological Monitoring
Brain Disorders
business
Neuroscience
030217 neurology & neurosurgery
Zdroj: Nature biotechnology, vol 39, iss 9
Nature biotechnology
ISSN: 1546-1696
1087-0156
DOI: 10.1038/s41587-021-00897-5
Popis: Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson's disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation.
Databáze: OpenAIRE
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