The prognostic role of tumour‐infiltrating lymphocytes in oral squamous cell carcinoma: A meta‐analysis
| Autor: | Zhengxian Huang, Yuehan Wan, Jinsong Hou, Han Zhou, Yue Zhu, Hai-chao Liu, Nan Xie, Xiqiang Liu, Cheng Wang, Ming Zhang, Yifan Tao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Poor prognosis chemical and pharmacologic phenomena Pathology and Forensic Medicine 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Immune system Tumor Microenvironment medicine Humans Basal cell CD68 business.industry Macrophages hemic and immune systems 030206 dentistry Prognosis medicine.disease stomatognathic diseases Otorhinolaryngology 030220 oncology & carcinogenesis Meta-analysis Carcinoma Squamous Cell Cancer research Periodontics Mouth Neoplasms Oral Surgery business CD163 Infiltration (medical) CD8 |
| Zdroj: | Journal of Oral Pathology & Medicine. 48:788-798 |
| ISSN: | 1600-0714 0904-2512 |
| Popis: | It has been suggested that tumour-infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta-analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta-analysis. Our pooled meta-analysis showed that high infiltration of CD8+ TILs, CD45RO+ TILs and CD57+ TILs favoured better overall survival (OS). However, high infiltration of CD68+ macrophages and CD163+ macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8+ TILs, CD45RO+ TILs, CD57+ TILs, CD68+ macrophages and CD163+ macrophages might serve as novel prognostic factors and therapeutic targets in OSCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text