Clinical correlates of renal dysfunction in hypertensive patients without cardiovascular complications: the REDHY study
| Autor: | Giuseppe Mulè, Marco Guarneri, Giovanni Cerasola, Rosalia Arsena, Paola Cusimano, Emilio Nardi, Calogero Geraci, Santina Cottone, Alessandro Palermo |
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| Přispěvatelé: | Cerasola, G, Mule', G, Nardi, E, Cusimano, P, Palermo, A, Arsena, R, Guarneri, M, Geraci, C, Cottone, S |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty arterial hypertension Waist estimated glomerular filtration rate Renal function Disease urologic and male genital diseases albuminuria Risk Factors Internal medicine renal dysfunction Internal Medicine medicine Humans Aged Kidney business.industry Middle Aged medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure Blood pressure Endocrinology Logistic Models Cardiovascular Diseases Chronic Disease Hypertension Cardiology Albuminuria Original Article Female Kidney Diseases medicine.symptom Complication business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Journal of Human Hypertension Scopus-Elsevier |
| ISSN: | 1476-5527 0950-9240 |
| Popis: | Our study was aimed to assess the clinical correlates of different degrees of renal dysfunction in a wide group of non-diabetic hypertensive patients, free from cardiovascular (CV) complications and known renal diseases, participating to the REDHY (REnal Dysfunction in HYpertension) study. A total of 1856 hypertensive subjects (mean age: 47+/-14 years), attending our hypertension centre, were evaluated. The glomerular filtration rate (GFR) was estimated by the simplified Modification of Diet in Renal Disease Study prediction equation. A 24-h urine sample was collected to determine albumin excretion rate (AER). Albuminuria was defined as an AER greater than 20 mug min(-1). We used the classification proposed by the US National Kidney Foundation's guidelines for chronic kidney disease (CKD) to define the stages of renal function impairment. In multiple logistic regression analysis, the probability of having stage 1 and stage 2 CKD was significantly higher in subjects with greater values of systolic blood pressure (SBP) and with larger waist circumference. SBP was also positively related to stage 3 CKD. Stage 3 and stages 4-5 CKD were inversely associated with waist circumference and directly associated with serum uric acid. Age was inversely related to stage 1 CKD and directly related to stage 3 CKD. The factors associated with milder forms of kidney dysfunction are, in part, different from those associated with more advanced stages of renal function impairment.Journal of Human Hypertension advance online publication |
| Databáze: | OpenAIRE |
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