Changes in serum and urine lysozyme activity after kidney transplantation: influence of graft function and therapy with azathioprine
| Autor: | Schröder K, Mebel M, Zinsmeyer J, Horpacsy G |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Azathioprine Urine Leukocyte Count chemistry.chemical_compound Internal medicine medicine Humans Transplantation Homologous Kidney transplantation chemistry.chemical_classification Catabolism Biochemistry (medical) Immunosuppression medicine.disease Kidney Transplantation Transplantation Kidney Tubules Endocrinology Enzyme chemistry Immunology Muramidase Lysozyme medicine.drug |
| Zdroj: | Clinical Chemistry. 24:74-79 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1093/clinchem/24.1.74 |
| Popis: | We investigated changes in lysozyme activity in serum and urine of kidney-transplant patients, and found that the production and catabolism of lysozyme in such patients differs markedly from that in normal subjects. Resumption of graft function decreases the high serum lysozyme activity by increasing the rate of catabolism in the transplant; at the same time, however, the production is inhibited by therapy with azathioprine. Changes in serum lysozyme activity correlate well with leukocyte count; thus its determination might be useful in monitoring immunosuppression. The urinary excretion of the enzyme, although not specific to rejection, is a good index of the degree of tubular damage. |
| Databáze: | OpenAIRE |
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