Inhibition of miRNA-221 suppresses the airway inflammation in asthma
| Autor: | Juan-juan Mei, Feng Liu, Dan Li, De-yu Zhao, Juan-juan Liu, Hou-bing Qin, Bing Xu |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Ovalbumin Immunology Inflammation Pathogenesis Mice Random Allocation Internal medicine microRNA medicine Respiratory Hypersensitivity Immunology and Allergy Animals Humans Child Asthma Mice Inbred BALB C biology business.industry Airway inflammation respiratory system medicine.disease Rheumatology respiratory tract diseases Blockade Disease Models Animal MicroRNAs Child Preschool biology.protein medicine.symptom business |
| Zdroj: | Inflammation. 35(4) |
| ISSN: | 1573-2576 |
| Popis: | This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy in the OVA-induced murine asthma model. miRNA-221 was differentially expressed in asthmatics and control subjects, and miRNA-221 blockade resulted in a reduction of airway inflammation in the OVA-induced murine asthma model. We conclude that miRNA-221 participates in the pathogenesis of asthma and that inhibition of miRNA-221 suppresses airway inflammation in asthmatics. |
| Databáze: | OpenAIRE |
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