Efficacy of individualized homeopathic medicines in intervening with the progression of pre-hypertension to hypertension: A double-blind, randomized, placebo-controlled trial
| Autor: | Munmun Koley, Subhasish Ganguly, Priyanka Ghosh, Subhranil Saha, Satarupa Sadhukhan, Shyamal Kumar Mukherjee, Sk Swaif Ali, Souvik Dutta, Pallavi Hazra, Abdur Rahaman Shaikh, Aniket Singha Roy |
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| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Placebo-controlled study Context (language use) 030204 cardiovascular system & hematology Placebo Prehypertension law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans 030212 general & internal medicine Adverse effect General Nursing business.industry Homeopathy Treatment Outcome Blood pressure Complementary and alternative medicine Hypertension Materia Medica Chiropractics business Analysis |
| Zdroj: | EXPLORE. 18:279-286 |
| ISSN: | 1550-8307 |
| Popis: | Context Pre-hypertension remains a significant public health challenge and appropriate intervention is required to stop its progression to hypertension and/or cardiovascular diseases. Objective To study the effects of individualized homeopathic medicines (IH) against placebo in intervening with the progression of pre-hypertension to hypertension. Design Double-blind, randomized, two parallel arms, placebo-controlled trial. Setting Outpatient departments of D. N. De Homoeopathic Medical College and Hospital, Kolkata, West Bengal, India. Patients Ninety-two patients suffering from pre-hypertension; randomized to receive either IH (n = 46) or identical-looking placebo (n = 46). Interventions IH or placebo in the mutual context of lifestyle modification (LSM) advices including dietary approaches to stop hypertension (DASH) and brisk exercises. Main outcome measures Primary – systolic and diastolic blood pressure (SBP and DBP); secondary – Measure Yourself Medical Outcome Profile version 2.0 (MYMOP-2) scores; all measured at baseline, and every month, up to 3 months. Results After 3 months of intervention, the number of patients having progression from pre-hypertension to hypertension between groups were similar without any significant differences in between (all P>0.05). Reduction in BP and MYMOP-2 scores were non-significantly higher (all P>0.05) in the IH group than placebo with small effect sizes. Lycopodium clavatum, Thuja occidentalis and Natrum muriaticum were the most frequently prescribed medicines. No harms or serious adverse events were reported from either group. Thus, there was a small, but non-significant direction of effect favoring homeopathy, which ultimately rendered the trial as inconclusive. [Trial registration: CTRI/2018/10/016,026; UTN: U1111–1221–8251] |
| Databáze: | OpenAIRE |
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