The Role of Ceruloplasmin in Neurodegeneration in Parkinson’s Disease
| Autor: | Nihal Isik, Reyhan Gürer, Dilvin Gökçe, Şenay Aydın, Tunahan Ayaz |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
Parkinson's disease
Idiopathic Parkinson's disease biology business.industry Neurodegeneration bacterial infections and mycoses proton magnetic resonance spectroscopy medicine.disease ceruloplasmin nervous system Idiopathic Parkinson’s disease mental disorders Immunology medicine biology.protein Medicine Neurology. Diseases of the nervous system Neurology (clinical) RC346-429 Ceruloplasmin business |
| Zdroj: | Türk Nöroloji Dergisi, Vol 22, Iss 1, Pp 19-25 (2016) |
| ISSN: | 1301-062X 0003-7753 |
| Popis: | WOS: 000377538300005 Objective: Oxidative stress has been implicated to play a major role in the neuronal cell death in idiopathic Parkinson's disease (IPD). Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form and thus helps prevent oxidative damage to proteins, lipids, and DNA. The aim of this study was to determine the serum ceruloplasmin levels in patients with IPD and evaluate its role in neurodegeneration using hydrogen proton magnetic resonance spectroscopic imaging (H-1 MRSI). Materials and Methods: Twenty-three patients with the IPD and 12 healthy controls were studied using single-voxel H-1 MRSI of the bilateral putamen. The peak ratios of N-acetyl aspartate (NAA) to creatinine (Cr) and choline (Cho) were measured in both groups and serum ceruloplasmin levels were detected. Results: Compared with the controls, the ratios of NAA/Cho and NAA/Cr in putamen contralateral (CL) to the symptomatic limbs were significantly lower in patients with IPD. Also in the IPD group, CL NAA/Cho and NAA/Cr ratios were significantly lower than the ipsilateral (IL) values (p |
| Databáze: | OpenAIRE |
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