Investigation of the bone density in multiple sclerosis

Autor:	V. D. Zavadovskaya, O. S. Dranichnikova, V. M. Alifirova
Rok vydání:	2008
Předmět:	Pathology medicine.medical_specialty Bone density business.industry Multiple sclerosis костная прочность bone density osteopenic syndrome multiple sclerosis medicine.disease рассеянный склероз medicine Medicine Molecular Medicine business остеопенический синдром
Zdroj:	Bûlleten' Sibirskoj Mediciny, Vol 7, Iss 2, Pp 46-51 (2008)
ISSN:	1819-3684 1682-0363
DOI:	10.20538/1682-0363-2008-2-46-51
Popis:	A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6111566ab3a6a1a81ff9d69b40ca59d https://doi.org/10.20538/1682-0363-2008-2-46-51 Zobrazit plný text záznamu