P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
Autor: | Karl-Dimiter Bissig, Francis P. Pankowicz, Liang Ding, Xinxin Ding, Nataliia Kovalchuk, Qing Yu Zhang, Mercedes Barzi, Weiguo Han, Xiaoyu Fan |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pharmaceutical Science Computational biology Biology 030226 pharmacology & pharmacy Xenobiotics 03 medical and health sciences Mice 0302 clinical medicine Cytochrome P-450 Enzyme System Animals Humans Pharmacology Human liver Special Section – New Models in Drug Metabolism and Transport Chimera Experimental Animal Models Key features Disease Models Animal 030104 developmental biology Liver metabolism Drug development Liver Toxicity Humanized mouse Inactivation Metabolic Models Animal Drug metabolism |
Zdroj: | Drug metabolism and disposition: the biological fate of chemicals. 46(11) |
ISSN: | 1521-009X |
Popis: | Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies. |
Databáze: | OpenAIRE |
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