Short-term effects of transjugular intrahepatic portosystemic shunt (TIPS) on functional liver plasma flow in patients with advanced cirrhosis
| Autor: | Mauro Torchio, Gianpaolo Molino, Stefania Battista, F. Bar, E Zanon, Spalluto F, Enrico Garello, Maurizio Grosso |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Portal venous pressure medicine.medical_treatment Urology Hemodynamics Gastroenterology Internal medicine medicine Humans Aged Hepatology business.industry Stent Middle Aged medicine.disease Hyperdynamic circulation Portal hypertension Female Liver function Portasystemic Shunt Transjugular Intrahepatic business Transjugular intrahepatic portosystemic shunt Liver Circulation |
| Zdroj: | Liver. 18(4) |
| ISSN: | 0106-9543 |
| Popis: | —Aims/Background: TIPS, an effective procedure applied for the treatment of complications of portal hypertension, is potentially followed by worsening of the hyperdynamic circulation of cirrhosis and the impairment of liver function. The aim of the present study was to evaluate short-term changes of functional liver plasma flow after application of TIPS, using the hepatic (extrarenal) clearance of D-sorbitol (S-HCl). Methods: Twenty-five cirrhotic patients submitted to TIPS for prevention of variceal rebleeding entered the study. At steady-state, during constant infusion of a solution of D-sorbitol (25 mg/min), appropriate blood and urine samples were collected in order to calculate S-HCl before and 120 min after TIPS opening. In addition, the hepatic extraction ratio of D-sorbitol was directly measured at the level of the right (Er), where TIPS was applied, and of the left (El) hepatic veins; meanwhile the portocaval gradient (PCG) was registered, before and after stent dilation. A comparison of values obtained before and after TIPS application was performed by Student's t-test for paired data. Results: After application of TIPS, a substantial reduction was observed in PCG (12.1 ± 4.2 vs 24.8 ± 4.3 mmHg; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text