The effect of trabeculectomy surgery on the central visual field in patients with glaucoma using microperimetry and optical coherence tomography
Autor: | John F Salmon, Gokulan Ratnarajan, Imran H. Yusuf, Jasleen K Jolly |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty genetic structures medicine.medical_treatment Glaucoma Trabeculectomy Article 03 medical and health sciences Young Adult 0302 clinical medicine Nerve Fibers Optical coherence tomography Glaucoma surgery Medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Intraocular Pressure Aged Aged 80 and over medicine.diagnostic_test business.industry Middle Aged medicine.disease eye diseases Surgery Visual field Ophthalmology medicine.anatomical_structure Treatment Outcome 030221 ophthalmology & optometry Visual Field Tests Female sense organs Visual Fields business Microperimetry Tomography Optical Coherence Optic disc |
Popis: | Purpose To determine the functional and structural effects of trabeculectomy surgery on patients with advanced glaucoma and central visual field defects in the early post-operative period. Methods Thirty consecutive adult subjects with advanced glaucoma requiring trabeculectomy surgery and an established visual field defect within 10° of fixation underwent microperimetry (MAIA MP-1, CenterVue, Padova, Italy) and optic disc optical coherence tomography (OCT) imaging (Spectralis, Heidelberg Engineering, Germany) pre-operatively, and 1 month and 3 months following trabeculectomy surgery. Main outcome measures were post-trabeculectomy change in mean threshold on microperimetry and nerve fibre layer thickness on OCT. Fellow eyes were used as controls. Results The mean change in MP average threshold values from pre-operative to post-operative was 0.6 ± 1.9 dB for treated eyes and 0.1 ± 1.3 dB for control eyes (p = 0.14) at 1 month and 0.2 ± 2.3 and −0.3 ± 1.6 dB at 3 months (p = 0.22). Mean change in global nerve fibre layer thickness was −0.6 and −0.5 µm for operated and control eyes, respectively (p = 0.83), at 1 month and 0.8 and −0.4 µm at 3 months (p = 0.88). The kappa agreement for structure–function correlation between OCT and MP was 0.735 (confidence interval 0.59–0.88) (p Conclusions Central visual function and retinal nerve fibre layer thickness appear to be preserved in glaucoma patients with central visual field defects undergoing trabeculectomy surgery in the early post-operative period. These data may inform glaucoma surgeons considering trabeculectomy surgery in this patient group. |
Databáze: | OpenAIRE |
Externí odkaz: |