Analysis of which local set-up errors can be covered by a 5-mm margin for cone beam CT-guided radiotherapy for nasopharyngeal carcinoma
| Autor: | Renming Zhong, Xuetao Wang, Yuying Yan, Jidan Zhou, Sen Bai, Xiaoyu Li, Shuai Li, Ying Song |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Planning target volume Computed tomography Radiotherapy Setup Errors 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Margin (machine learning) medicine Humans Radiology Nuclear Medicine and imaging Correlation test Cone beam ct Aged Nasopharyngeal Carcinoma Full Paper medicine.diagnostic_test Receiver operating characteristic business.industry Carcinoma Nasopharyngeal Neoplasms General Medicine Cone-Beam Computed Tomography Middle Aged medicine.disease Radiation therapy Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Female business Nuclear medicine Radiotherapy Image-Guided |
| Zdroj: | The British Journal of Radiology |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/bjr.20160849 |
| Popis: | Objective: To analyse which local set-up errors can be covered by a 5-mm margin for cone beam computed tomography (CBCT)-guided radiotherapy in nasopharyngeal carcinoma (NPC). Methods: 11 regions of interest (ROIs) were registered for 24 NPC patients, with a total of 323 CBCT scans. According to the registration results, clinical target volume–planning target volume (CTV–PTV)/organs at risk-planning risk volume (OAR-PRV) margin analysis; Pearson correlation analysis; Bland–Altman plots; and a receiver operating characteristic (ROC) analysis were used to investigate which local set-up errors of substructure can be represented by the PTVROI. Results: The clinical target volume-PTV/OAR-planning risk volume margins were less than 5 mm for C1ROI-C4ROI, mandible (MROI), and sphenoid sinus (SROI) with respect to PTVROI. C1ROI-C4ROI, MROI, and SROI exhibited significant correlations and consistencies in the mediolateral, superior–inferior, and anteroposterior (AP) directions and significant receiver operating characteristic analysis results in the anteroposterior direction. Conclusion: Only the upper local set-up error of C1ROI-C4ROI, MROI, and SROI can be covered by a 5-mm margin for CBCT-guided NPC radiotherapy with a large ROI. Using these ROIs as an integral reference ROI is better than individual bony landmark. Advances in knowledge: This report is helpful to CBCT registration for NPC radiotherapy in clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|