Opiatergic mechanisms of the antiarrhythmic effect of adaptation
| Autor: | Yu. B. Lishmanov, E. V. Uskina, A. V. Krylatov, Leonid N. Maslov |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Enkephalin business.industry Endogeny General Medicine (+)-Naloxone Pharmacology General Biochemistry Genetics and Molecular Biology Endocrinology Epinephrine Internal medicine Blood plasma medicine Enkephalinase inhibitor Antiarrhythmic effect business Opioid peptide medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02446573 |
| Popis: | A decrease in the severity and occurrence of epinephrine- and CaCl2-induced cardiac arrhythmias and an increase in the β-endorphin and enkephalin contents in the brain, myocardium, adrenals, and blood plasma are observed in rats adapted to stress. The antiarrhythmic effect of adaptation is abolished by naloxone. A single administration of D-kyotorphin, a liberator of endogenous peptides, to intact animals also increases the resistance to arrhythmogenic factors. Intravenous administration of the enkephalinase inhibitor RB101 produces a significant antiarrhythmic effect in control animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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