Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection
| Autor: | Kaj Blennow, Lars Hagberg, Dietmar Fuchs, Markus Axelsson, Magnus Gisslén, Jan Lycke, Linn Hermansson, Henrik Zetterberg, Aylin Yilmaz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine medicine.medical_specialty YKL-40 Neurology Immunology Central nervous system HIV Infections Neopterin lcsh:RC346-429 Pathogenesis 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Cerebrospinal fluid Neurofilament Proteins Humans Neurofilament protein Medicine Dementia Chitinase-3-Like Protein 1 Correlation of Data lcsh:Neurology. Diseases of the nervous system business.industry Research General Neuroscience Albumin HIV Middle Aged medicine.disease 3. Good health Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure chemistry Brain Injuries Cytokines Biomarker (medicine) Female business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroinflammation Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-9 (2019) |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-019-1404-9 |
| Popis: | Background HIV-1 infects the central nervous system (CNS) shortly after transmission. This leads to a chronic intrathecal immune activation. YKL-40, a biomarker that mainly reflects activation of astroglial cells, has not been thoroughly investigated in relation to HIV. The objective of our study was to characterize cerebrospinal fluid (CSF) YKL-40 in chronic HIV infection, with and without antiretroviral treatment (ART). Methods YKL-40, neopterin, and the axonal marker neurofilament light protein (NFL) were analyzed with ELISA in archived CSF samples from 120 HIV-infected individuals (85 untreated neuroasymptomatic patients, 7 with HIV-associated dementia, and 28 on effective ART) and 39 HIV-negative controls. Results CSF YKL-40 was significantly higher in patients with HIV-associated dementia compared to all other groups. It was also higher in untreated neuroasymptomatic individuals with CD4 cell count |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink