Genetic characterization of Chikungunya virus circulating in individuals from Paraná, Brazil

Autor: Deborah de Castro Moreira, Francisco Ferreira Duarte Junior, José Renato Pattaro Júnior, Fernando Américo Jorge, Fabiana dos Santos Rando, Mateus Vaillant Thomazella, Mayra Marinho Presibella, Irina Nastassja Riediger, Maria Aparecida Fernandez, Dennis Armando Bertolini
Rok vydání: 2022
Předmět:
Zdroj: Braz J Microbiol
ISSN: 1678-4405
1517-8382
DOI: 10.1007/s42770-022-00680-x
Popis: Phylogenetic analysis carried out in several Brazilian regions shows the circulation of the Asian and East-Central South African (ECSA) Chikungunya virus (CHIKV) genotypes in the country. Until now, there are no genetic studies about CHIKV strains circulating in the South region. In this study, we sequenced 5 new partial sequences of the CHIKV Envelope 1 gene from strains detected in Paraná state during the years 2016–2017. Maximum likelihood and neighbor-joining trees grouped all sequences in Brazilian branches within ECSA genotype and comparative analysis did not show E1-A226V mutation. However, we identified E1-K211T amino acid substitution in a sample demonstrating the dispersion of mutant strains in the country. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42770-022-00680-x.
Databáze: OpenAIRE
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