Studies on Anti-Allergic Components in the Roots ofAsiasarum sieboldi
| Autor: | Yuki Okui, Masao Maruno, Kazunori Hashimoto, Tetsuro Fujita, Toshihiko Yanagisawa, Yukinobu Ikeya |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Guinea Pigs Pharmaceutical Science Analytical Chemistry Guinea pig chemistry.chemical_compound Lipoxygenase In vivo Drug Discovery Hypersensitivity Animals Pharmacology Molecular Structure biology Traditional medicine Organic Chemistry Elemicin Biological activity biology.organism_classification In vitro Rats Complementary and alternative medicine chemistry Methyleugenol biology.protein Molecular Medicine Aristolochiaceae Drugs Chinese Herbal |
| Zdroj: | Planta Medica. 60:124-127 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-959432 |
| Popis: | The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenami de (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD4. |
| Databáze: | OpenAIRE |
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