Childhood acute myeloid leukemia withCBF?-MYH11 rearrangement: Study of incidence, morphology, cytogenetics, and clinical outcomes of Chinese in Hong Kong
| Autor: | Natalie P. H. Chan, Kam Sze Tsang, Tai Tap Lau, Yonna Leung, Wai-Shan Wong, Margaret H.L. Ng, Mathew M.K. Shing, K. W. Chik, Chi K. Li |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Concordance Bone Marrow Recurrence Internal medicine Epidemiology medicine Humans Eosinophilia RNA Messenger Child Chromosome Aberrations Hematology Myosin Heavy Chains Reverse Transcriptase Polymerase Chain Reaction business.industry Incidence (epidemiology) Remission Induction Childhood Acute Myeloid Leukemia Cytogenetics Infant Gene rearrangement DNA-Binding Proteins Survival Rate Leukemia Myeloid Acute Transcription Factor AP-2 Child Preschool Female medicine.symptom business Chromosomes Human Pair 16 Transcription Factors |
| Zdroj: | American Journal of Hematology. 76:300-303 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.20081 |
| Popis: | We analyzed 43 consecutive cases of pediatric acute myeloid leukemia (AML) for the presence of the CBFβ-MYH11 rearrangement using molecular techniques in a regional hospital in Hong Kong. Five cases (11.6%), 3 girls and 2 boys, ranging in age from 8 months to 14 years old, were found positive for the CBFβ-MYH11 rearrangement. Morphologically, they were FAB M2 or M4 with or without eosinophilia (Eo). Typical M4Eo was observed in only one case. The molecular findings were in complete concordance with cytogenetic data, which revealed inv(16)(p13q22) in all and also gains of chromosome 4, 8, 22, and Y in one patient. Clinically, all 5 patients achieved complete remission after chemotherapy with favorable outcomes except for the patient with infantile AML, who relapsed 11 months after diagnosis, underwent cord blood transplantation, and was in second remission. This is the first clinicopathological study and documentation of the incidence of CBFβ-MYH11 in childhood AML of Chinese in Hong Kong. Am. J. Hematol. 76:300–303, 2004. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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