Predictive factors and clinical biomarkers for treatment in patients with chronic pain caused by osteoarthritis with a central sensitisation component
Autor: | W. Tassanawipas, M. Al Shaker, Yong Chul Kim, Y. Wang, Danilov Ab, R. Guillen, Tamas Treuer, H. José Dueñas, Ayşen Akıncı, M. H. Chang, C. W. Cheung |
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Přispěvatelé: | Fiziksel Tıp ve Rehabilitasyon |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Nociception
Pathology medicine.medical_specialty Osteoarthritis Review Article Review 03 medical and health sciences 0302 clinical medicine Risk Factors Chronic osteoarthritis medicine Humans In patient Intensive care medicine Pain Measurement 030203 arthritis & rheumatology Central Nervous System Sensitization business.industry Mechanism (biology) Functional Neuroimaging Chronic pain General Medicine medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Clinical diagnosis Chronic Pain business 030217 neurology & neurosurgery Biomarkers |
Zdroj: | International Journal of Clinical Practice |
ISSN: | 1742-1241 1368-5031 |
Popis: | Summary Aims The aim of this non‐systematic review was to provide a practical guide for clinicians on the evidence for central sensitisation in chronic osteoarthritis (OA) pain and how this pain mechanism can be addressed in terms of clinical diagnosis, investigation and treatment. Methods The authors undertook a non‐systematic review of the literature including a MEDLINE search (search terms included central sensitisation, osteoarthritis, osteoarthrosis) for relevant and current clinical studies, systematic reviews and narrative reviews. Case reports, letters to the editor and similar literature sources were excluded. Information was organised to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations. Results There is good evidence for a role of central sensitisation in chronic OA pain in a subgroup of patients. Clinically, a central sensitisation component in chronic OA pain can be suspected based on characteristic pain features and non‐pain features seen in other conditions involving central sensitisation. However, there are currently no diagnostic inventories for central sensitisation specific to OA. Biomarkers may be helpful for confirming the presence of central sensitisation, especially when there is diagnostic uncertainty. Several non‐pharmacological and pharmacological treatments may be effective in OA patients with central sensitisation features. Multimodal therapy may be required to achieve control of symptoms. Discussion Clinicians should be aware of central sensitisation in patients with chronic OA pain, especially in patients presenting with severe pain with unusual features. |
Databáze: | OpenAIRE |
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