IDH1 and IDH2 hotspot mutations are not found in canine glioma

Autor:	Roger E. McLendon, Zachary J. Reitman, Darrell D. Bigner, Hai Yan, Christopher L. Mariani, Matthew Breen, Natasha J. Olby, Rachael Thomas
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Cancer Research IDH1 Somatic cell Brain Neoplasms Glioma Biology medicine.disease Isozyme Molecular biology IDH2 Article Isocitrate Dehydrogenase nervous system diseases Isoenzymes Isocitrate dehydrogenase Dogs Oncology Canine Glioma Mutation medicine Animals neoplasms Anaplastic astrocytoma
Popis:	Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaplastic oligodendrogliomas and secondary glio-blastomas frequently (>70%) contain somatic mutations ofthe R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e605f4ee6a14a0c8767955b9423a6e52 https://europepmc.org/articles/PMC3498760/ Zobrazit plný text záznamu