Tryptophan Excited States and Cataracts in the Human Lens
| Autor: | Myron L. Wolbarsht, R. B. Kurzel, R. F. Borkman, G. W. Staton, B.S. Yamanashi |
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| Rok vydání: | 1973 |
| Předmět: |
Multidisciplinary
Materials science genetic structures Absorption spectroscopy business.industry Tryptophan Crystallins Fluorescence Cataract eye diseases Wavelength Spectrometry Fluorescence medicine.anatomical_structure Optics Cornea Lens Crystalline medicine Ultraviolet light Biophysics Humans Human eye sense organs Absorption (electromagnetic radiation) business Action spectrum |
| Zdroj: | Nature. 241:132-133 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/241132a0 |
| Popis: | WE present here a study of the fluorescence and phosphorescence of human eye lenses in vitro with regard to the mechanisms of formation of cataracts. Light transmission by the cornea decreases rapidly with decreasing wavelength, and is essentially zero for wavelengths less than 293 nm1–3. The important effect of this corneal absorption was demonstrated by Bachem3 who induced cataracts in guinea-pigs and rabbits with ultraviolet light and presented an action spectrum to show that the efficiency of in vivo cataract production rose steeply, from zero at 293 nm to maximum at 300 nm, and then fell off sharply at 313 nm with a long tail extending to about 365 nm. This action spectrum and the corneal absorption spectrum are shown in Fig. 1. |
| Databáze: | OpenAIRE |
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