Does modifying the timing of meal intake improve cardiovascular risk factors? Protocol of an Australian pilot intervention in night shift workers with abdominal obesity
Autor: | Nina Eikelis, Maxine P. Bonham, Chiara Murgia, Morag J. Young, Rochelle Davis, Catherine E. Huggins, Elisabeth Lambert, Tracey L. Sletten, Gloria K. W. Leung |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
Adult
Male 030209 endocrinology & metabolism postprandial Pilot Projects Disease Shift work lipids 03 medical and health sciences Young Adult 0302 clinical medicine cardiovascular disease Risk Factors Environmental health Surveys and Questionnaires Work Schedule Tolerance medicine Protocol Humans 030212 general & internal medicine Risk factor Meals Abdominal obesity Meal Nutrition and Metabolism Cross-Over Studies business.industry Australia General Medicine glycaemia Feeding Behavior Middle Aged Postprandial Period Circadian Rhythm Postprandial Health promotion shift work Cardiovascular Diseases Female Analysis of variance medicine.symptom business Energy Intake |
Zdroj: | BMJ Open |
ISSN: | 2044-6055 |
Popis: | IntroductionShift work is an independent risk factor for cardiovascular disease (CVD). Shift workers who are awake overnight and sleep during the day are misaligned with their body’s endogenous circadian rhythm. Eating at night contributes to this increased risk of CVD by forcing the body to actively break down and process nutrients at night. This pilot study aims to determine whether altering meal timing overnight, in a shift working population, will impact favourably on modifiable risk factors for CVD (postprandial bplasma lipids and glucose concentration).Methods and analysisA randomised cross-over study with two 4-week test periods, separated by a minimum of a 2-week washout will be undertaken. The effectiveness of redistributing energy intake overnight versusad libitumeating patterns on CVD risk factors will be examined in night shift workers (n=20), using a standard acute test meal challenge protocol. Primary outcomes (postprandial lipids and glucose) will be compared between the two conditions: post-intervention and post-control period using analysis of variance. Potential effect size estimates to inform sample size calculations for a main trial will also be generated.Ethics and disseminationEthics approval has been granted by the Monash University Human Research Ethics Committee (2017-8619-10329). Outcomes from this study will determine whether eliminating food intake for a defined period at night (1–6 am) impacts favourably on metabolic risk factors for CVD in night shift workers. Collective results from this novel trial will be disseminated through peer-reviewed journals, and national and international presentations. The results are essential to inform health promotion policies and guidelines for shift workers, especially those who aim to improve their metabolic health.Trial registration numberACTRN12617000791336; Pre-results. |
Databáze: | OpenAIRE |
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