Resolution of a hepatoduodenal fistula after nivolumab treatment in a patient with hepatocellular carcinoma: challenges in immunotherapy
| Autor: | E Vanderstraeten, Vincent Bouderez, Christophe Van Steenkiste, E. Monsaert, Thomas De Somer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology Sorafenib medicine.medical_specialty Carcinoma Hepatocellular Fistula medicine.medical_treatment Multikinase inhibitor 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged 80 and over business.industry Liver Neoplasms General Medicine Immunotherapy medicine.disease digestive system diseases Immune checkpoint Nivolumab Parenteral nutrition 030220 oncology & carcinogenesis Hepatocellular carcinoma Human medicine business medicine.drug |
| Zdroj: | Acta clinica Belgica |
| ISSN: | 2295-3337 1784-3286 |
| DOI: | 10.1080/17843286.2020.1778346 |
| Popis: | Hepatocellular carcinoma is the fourth leading cause of cancer-related death worldwide, with limited treatment options for patients with advanced hepatocellular carcinoma. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for a robust and durable response with immune checkpoint inhibition in subsets of patients with hepatocellular carcinoma. We present a case of an 83-year-old male patient with the diagnosis of a multifocal hepatocellular carcinoma. A hepatoduodenal fistula developed under treatment with sorafenib which necessitated treatment interruption. Therefore, a switch to second line therapy with immunotherapy nivolumab was made and supportive enteral nutrition was started. This led to a spectacular oncological response, with complete resolution of the hepatoduodenal fistula. To our knowledge this is the first case which describes the involution of a fistula in a hepatocellular carcinoma under treatment with nivolumab. |
| Databáze: | OpenAIRE |
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