A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles
| Autor: | Bai-Yu Lee, Daniel L. Clemens, Marcus A. Horwitz, Bastian Ruehle, Jeffrey I. Zink |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.drug_class
Antibiotics Nanotechnology 02 engineering and technology Select agent 010402 general chemistry medicine.disease_cause 01 natural sciences Biochemistry Catalysis Microbiology Colloid and Surface Chemistry medicine Pathogen Francisella tularensis biology Chemistry Pseudomonas aeruginosa General Chemistry Mesoporous silica 021001 nanoscience & nanotechnology biology.organism_classification 0104 chemical sciences Francisella 0210 nano-technology Bacteria |
| Zdroj: | Journal of the American Chemical Society. 139:6663-6668 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.7b01278 |
| Popis: | We present a synthetic approach to a highly pathogen-selective detection and delivery platform based on the interaction of an antibody nanovalve with a tetrasaccharide from the O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent of bioterrorism. Different design considerations are explored, and proof-of-concept for highly pathogen-specific cargo release from mesoporous silica nanoparticles is demonstrated by comparisons of the release of a signal transducer and model drug by LPS from F. tularensis vs Pseudomonas aeruginosa and by F. tularensis live bacteria vs the closely related bacterium Francisella novocida. In addition to the specific response to a biowarfare agent, treatment of infectious diseases in general could benefit tremendously from a delivery platform that releases its antibiotic payload only at the site of infection and only in the presence of the target pathogen, thereby minimizing off-target toxicities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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